People_

Associate Professor Helen McGuire

BMedSci PhD UNSW

School of Medical Sciences, Faculty of Medicine and Health
International Society for Advancement of Cytometry Councillor and Marylou Ingram Scholar
Australasian Cytometry Society past President
Australian and NZ Society for Immunology NSW past Councillor

Email

[email protected]

Details

Member of Sydney Southeast Asia Centre

Member of the Charles Perkins Centre

Websites

LinkedIn Profile

International Society for Advancement of Cytometry

Australasian Cytometry Society

Biographical details

I obtained my PhD from the Garvan Institute of Medical Research, Sydney in 2011. I subsequently received an NHMRC postdoctoral fellowship, allowing me to undertake training at Stanford University, California. At Stanford, I was under the mentorship of Professor Mark Davis in the Institute for Immunity Transplantation and Infection, a pioneering lab in the use of single cell proteomics technology know as Cytometry by Time-Of-Flight or CyTOF.

Awards and honours

2019 Sydney Catalyst International Translational Cancer Research Symposium, best oral presentation

2013 Immunology Department, Stanford University Postdoctoral Fellow Mentor of the Year

2012 National Health and Medical Research Council (NHMRC)/Early Career Fellowship

Themes

Cancer, Infection and Immunological Conditions, Healthy Ageing

Keywords

Immune system diseases, Immunology, Infection and immunity, Inflammation, Melanoma and skin cancer

Approaches

Immunology, Translational Research, Treatment/Intervention

International links

United States

(Stanford University) Prof Mark Davis (Institute for Immunity, Transplantation and Infection)

Current research students

Project title	Research student
Investigation of critical immune regulators of response to checkpoint inhibitor immunotherapy in cancer.	Natalie SMITH
Understanding mesothelin biology and function to enhance the efficacy of MSLN-targeted therapies against pancreatic cancer	Shuwen YE

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Book Chapters

Smith, N., Maddahfar, M., Gunasegaran, B., McGuire, H., Fazekas de St Groth, B. (2023). A High-Throughput Colorimetric Microplate Assay for Determination of Plasma Arginase Activity. In Anna S. Kashina (Eds.), Protein Arginylation - Methods and Protocols, (pp. 273-286). United States: Humana Press. [More Information]
King, C., McGuire, H. (2014). The Immunobiology of Interleukin-21. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 496-506). New York: Springer Science+Business Media.

Journals

Huang, C., Siwan, E., Baker, C., Wei, Z., Shinko, D., McGuire, H., Twigg, S., Min, D. (2025). Uncovering Sex-Related Differences in Skin Macrophage Polarization During Wound Healing in Diabetic Mice. Frontiers in Bioscience - Landmark, 30(2), 27113. [More Information]
Tseng, H., Alavi, S., Gallagher, S., McGuire, H., Hersey, P., Emran, A., Tiffen, J. (2024). BET inhibition sensitizes innate checkpoint inhibitor resistant melanoma to anti-CTLA-4 treatment. Pigment Cell & Melanoma Research. [More Information]
Zhang, Z., Yang, H., Eshraghian, J., Li, J., Yong, K., Vigolo, D., McGuire, H., Kavehei, O. (2024). Cell detection with convolutional spiking neural network for neuromorphic cytometry. APL Machine Learning, 2, 026117-1-026117-8. [More Information]
Budden, K., Faiz, A., Patel, V., Donovan, C., Alemao, C., Shen, S., Amorim, N., Majumder, R., Vanka, K., Mason, J., Ashhurst, T., Van Vreden, C., McGuire, H., Fazekas de St Groth, B., King, N., Crossett, B., Cordwell, S., et al (2024). Faecal microbial transfer and complex carbohydrates mediate protection against COPD. Gut, 73(5), 751-769. [More Information]
Bate, K., Genetzakis, E., Vescovi, J., Gray, M., Celermajer, D., McGuire, H., Grieve, S., Vernon, S., Cartland, S., Yang, J., Kavurma, M., Figtree, G. (2024). Vascular Cytokines and Atherosclerosis: Differential Serum Levels of TRAIL, IL-18, and OPG in Obstructive Coronary Artery Disease. Biomolecules, 14, 1119. [More Information]
Louie, R., Cai, C., Samir, J., Singh, M., Deveson, I., Ferguson, J., Amos, T., McGuire, H., Gowrishankar, K., Adikari, T., Bishop, D., Gottlieb, D., Blyth, E., Micklethwaite, K., et al (2023). CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies. Nature Communications, 14(1). [More Information]
Stern, L., McGuire, H., Avdic, S., Blyth, E., Gottlieb, D., Patrick, E., Abendroth, A., Slobedman, B. (2023). Circulating cytokine and chemokine patterns associated with cytomegalovirus reactivation after stem cell transplantation. Clinical & Translational Immunology, 12(12), e16815-1-e16815-17. [More Information]
Kott, K., Chan, A., Vernon, S., Hansen, T., Kim, T., De Dreu, M., Gunasegaran, B., Murphy, A., Patrick, E., Psaltis, P., Grieve, S., Yang, J., Fazekas de St Groth, B., McGuire, H., Figtree, G. (2023). Mass cytometry analysis reveals altered immune profiles in patients with coronary artery disease. Clinical & Translational Immunology, 12(11), e1462-1-e1462-18. [More Information]
Guy, T., Terry, A., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2023). MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo. OncoImmunology, 13(1), 2290799. [More Information]
Su, Z., Diao, T., McGuire, H., Yao, C., Yang, L., Bao, G., Xu, X., He, B., Zheng, Y. (2023). Nanomaterials Solutions for Contraception: Concerns, Advances, and Prospects. ACS Nano, 17(21), 20753-20775. [More Information]
Zhang, Z., Xu, Z., McGuire, H., Essam, C., Nicholson, A., Hamilton, T., Li, J., Eshraghian, J., Yong, K., Vigolo, D., Kavehei, O. (2023). Neuromorphic cytometry: implementation on cell counting and size estimation. Neuromorphic Computing and Engineering, 3(4), 044005. [More Information]
Rose, C., McGuire, H., Graham, K., Siegler, J., Fazekas de St Groth, B., Caillaud, C., Edwards, K. (2023). Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings. European Journal of Applied Physiology, 123(2), 407-415. [More Information]
Jiang, W., Avdic, S., Lee, K., Street, J., Castellano-Gonzalez, G., Simms, R., Clancy, L., Blennerhassett, R., Patrick, E., Chan, A., McGuire, H., Myers, N., Gloss, B., Bateman, C., Micklethwaite, K., Gottlieb, D., Blyth, E., et al (2023). Persistence of ex vivo expanded tumour and pathogen specific T-cells after allogeneic stem cell transplant for myeloid malignancies (the INTACT study). Leukemia, 37(11), 2330-2333. [More Information]
Kott, K., Genetzakis, E., Gray, M., Hansen, P., McGuire, H., Yang, J., Grieve, S., Vernon, S., Figtree, G. (2023). Serum Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 (sLOX-1) Is Associated with Atherosclerosis Severity in Coronary Artery Disease. Biomolecules, 13(8), 1187-17 pages. [More Information]
Hey-Cunningham, A., Riaz, A., Fromm, P., Kupresanin, F., Markham, R., McGuire, H. (2022). Circulating and Endometrial Regulatory T Cell and Related Populations in Endometriosis and Infertility: Endometriosis Is Associated with Blunting of Endometrial Cyclical Effects and Reduced Proportions in Moderate-Severe Disease. Reproductive Sciences, 29(1), 229-242. [More Information]
Figtree, G., Kovacic, J., McGuire, H. (2022). Human susceptibility to coronary artery disease: lessons from chimpanzee resilience. Nature Reviews Cardiology, 19(8), 497-498. [More Information]
Stern, L., McGuire, H., Avdic, S., Fazekas de St Groth, B., Gottlieb, D., Abendroth, A., Blyth, E., Slobedman, B. (2022). Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation. Nature Communications, 13(1), 2603. [More Information]
Bell, K., Saad, S., Tillett, B., McGuire, H., Bordbar, S., Yap, Y., Nguyen, L., Wilkins, M., Corley, S., Brodie, S., Duong, S., Wright, C., Twigg, S., Fazekas de St Groth, B., et al (2022). Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation. Microbiome, 10(1). [More Information]
Alavi, S., Emran, A., Tseng, H., Tiffen, J., McGuire, H., Hersey, P. (2022). Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T Cells. Cancers, 14(2), 323. [More Information]
Marsh-Wakefield, F., Juillard, P., Ashhurst, T., Juillard, A., Shinko, D., Putri, G., Read, M., McGuire, H., Byrne, S., Hawke, S., Grau, G. (2022). Peripheral B-cell dysregulation is associated with relapse after long-term quiescence in patients with multiple sclerosis. Immunology and Cell Biology, 100(6), 453-467. [More Information]
Jiang, W., Clancy, L., Avdic, S., Sutrave, G., Street, J., Simms, R., McGuire, H., Patrick, E., Chan, A., McCaughan, G., Myers, N., Micklethwaite, K., Bateman, C., Shaw, P., Blyth, E., Gottlieb, D., et al (2022). Third-party CMV- and EBV-specific T-cells for first viral reactivation after allogeneic stem cell transplant. Blood Advances, 6(17), 4949-4966. [More Information]
Seddiki, N., Zaunders, J., Phetsouphanh, C., Brezar, V., Xu, Y., McGuire, H., Bailey, M., McBride, K., Hey-Cunningham, W., Munier, C., Fazekas de St Groth, B., et al (2021). CD73+ CD127high long-term memory CD4 T cells are highly proliferative in response to recall antigens and are early targets in hiv-1 infection. International Journal of Molecular Sciences, 22(2), 1-28. [More Information]
Hey-Cunningham, A., Wong, C., Hsu, J., Fromm, P., Clark, G., Kupresanin, F., Miller, E., Markham, R., McGuire, H. (2021). Comprehensive analysis utilizing flow cytometry and immunohistochemistry reveals inflammatory changes in local endometrial and systemic dendritic cell populations in endometriosis. Human Reproduction, 36(2), 415-428. [More Information]
Bishop, D., Clancy, L., Simms, R., Burgess, J., Mathew, G., Moezzi, L., Street, J., Sutrave, G., Atkins, E., McGuire, H., Lee, K., Jiang, W., McCaughan, G., Shaw, P., Gottlieb, D., Blyth, E., Micklethwaite, K., et al (2021). Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells. Blood, 138(16), 1504-1509. [More Information]
Jerram, A., Guy, T., Beutler, L., Gunasegaran, B., Sluyter, R., Fazekas de St Groth, B., McGuire, H. (2021). Effects of storage time and temperature on highly multiparametric flow analysis of peripheral blood samples; implications for clinical trial samples. Bioscience Reports, 41(2), BSR20203827. [More Information]
Marsh-Wakefield, F., Mitchell, A., Norton, S., Ashhurst, T., Leman, J., Roberts, J., Harte, J., McGuire, H., Kemp, R. (2021). Making the most of high-dimensional cytometry data. Immunology and Cell Biology, 99(7), 680-696. [More Information]
Gottlieb, D., Clancy, L., Withers, B., McGuire, H., Luciani, F., Singh, M., Hughes, B., Gloss, B., Kliman, D., Ma, C., Bishop, D., Dubosq, M., Li, Z., Avdic, S., Micklethwaite, K., Blyth, E., et al (2021). Prophylactic antigen-specific T-cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant. Clinical & Translational Immunology, 10(3), e1249. [More Information]
O'Brien, J., McGuire, H., Shinko, D., Fazekas de St Groth, B., Russo, M., Bailey, D., Santarelli, D., Wynne, K., Austin, P. (2021). T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain. Brain, Behavior, & Immunity - Health, 15, 100283. [More Information]
Norton, S., Leman, J., Khong, T., Spencer, A., Fazekas de St Groth, B., McGuire, H., Kemp, R. (2020). Brick plots: An intuitive platform for visualizing multiparametric immunophenotyped cell clusters. BMC Bioinformatics, 21(1), 145. [More Information]
Johnson, B., McAlister, S., McGuire, H., Palanivelu, V., Stevenson, A., Richmond, P., Palmer, D., Metcalfe, J., Prescott, S., Wood, F., Fazekas de St Groth, B., et al (2020). Corrigendum: Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response. Frontiers in Immunology, 11, 598646. [More Information]
Fromm, P., Silveira, P., Hsu, J., Papadimitrious, M., Lo, T., Ju, X., Kupresanin, F., Romano, A., Hsu, W., Bryant, C., Kong, B., Abadir, E., McGuire, H., Fazekas de St Groth, B., Hart, D., Clark, G., et al (2020). Distinguishing human peripheral blood CD16+ myeloid cells based on phenotypic characteristics. Journal of Leukocyte Biology, 107(2), 323-339. [More Information]
Emran, A., Tseng, H., Coleman, M., Tiffen, J., Cook, S., McGuire, H., Gallagher, S., Feng, C., Hersey, P. (2020). Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma? Pigment Cell & Melanoma Research, 33(5), 660-670. [More Information]
Lee, K., Gowrishankar, K., Street, J., McGuire, H., Luciani, F., Hughes, B., Singh, M., Clancy, L., Gottlieb, D., Micklethwaite, K., Blyth, E. (2020). Ex vivo enrichment of PRAME antigen-specific T cells for adoptive immunotherapy using CD137 activation marker selection. Clinical & Translational Immunology, 9(e1200), 1-13. [More Information]
Marsh-Wakefield, F., Ashhurst, T., Trend, S., McGuire, H., Juillard, P., Zinger, A., Jones, A., Kermode, A., Hawke, S., Grau, G., Byrne, S., et al (2020). IgG3+ B cells are associated with the development of multiple sclerosis. Clinical & Translational Immunology, 9(5), 1-13. [More Information]
Larsen, B., Cox, A., Colbey, C., Drew, M., McGuire, H., Fazekas de St Groth, B., Hughes, D., Vlahovich, N., Waddington, G., Burke, L., et al (2020). Inflammation and Oral Contraceptive Use in Female Athletes Before the Rio Olympic Games. Frontiers in Physiology, 11, 497. [More Information]
Vuckovic, S., Bryant, C., Lau, K., Yang, S., Favaloro, J., McGuire, H., Clark, G., Fazekas de St Groth, B., Marsh-Wakefield, F., Nassif, N., McCulloch, D., Brown, C., Larsen, S., Gibson, J., Joshua, D., Ho, P., et al (2020). Inverse relationship between oligoclonal expanded CD69- TTE and CD69+ TTE cells in bone marrow of multiple myeloma patients. Blood Advances, 4(19), 4593-4604. [More Information]
Zaunders, J., Munier, C., McGuire, H., Law, H., Howe, A., Xu, Y., Fazekas de St Groth, B., Schofield, P., Christ, D., Milner, B., Dyer, W., et al (2020). Mapping the extent of heterogeneity of human CCR5(+)CD4(+)T cells in peripheral blood and lymph node. AIDS, 34(6), 833-848. [More Information]
McGuire, H., Rizzetto, S., Withers, B., Clancy, L., Avdic, S., Stern, L., Patrick, E., Fazekas de St Groth, B., Slobedman, B., Gottlieb, D., Blyth, E., et al (2020). Mass cytometry reveals immune signatures associated with cytomegalovirus (CMV) control in recipients of allogeneic haemopoietic stem cell transplant and CMV-specific T cells. Clinical & Translational Immunology, 9(7), 1-16. [More Information]
Johnson, B., McAlister, S., McGuire, H., Palanivelu, V., Stevenson, A., Richmond, P., Palmer, D., Metcalfe, J., Prescott, S., Wood, F., Fazekas de St Groth, B., et al (2020). Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response. Frontiers in Immunology, 11, 1-15. [More Information]
Pirozyan, M., McGuire, H., Emran, A., Tseng, H., Tiffen, J., Lee, J., Carlino, M., Menzies, A., Long, G., Scolyer, R., Fazekas de St Groth, B., Hersey, P. (2020). Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients. Frontiers in Immunology, 11, 372. [More Information]
Castellano-González, G., McGuire, H., Luciani, F., Clancy, L., Li, Z., Avdic, S., Hughes, B., Singh, M., Fazekas de St Groth, B., Renga, G., Gottlieb, D., et al (2020). Rapidly expanded partially HLA DRB1-matched fungus-specific T cells mediate in vitro and in vivo antifungal activity. Blood Advances, 4(14), 3443-3456. [More Information]
Kott, K., Vernon, S., Hansen, T., De Dreu, M., Das, S., Powell, J., Fazekas de St Groth, B., Di Bartolo, B., McGuire, H., Figtree, G. (2020). Single-Cell Immune Profiling in Coronary Artery Disease: The Role of State-of-the-Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis. Journal of the American Heart Association, 9(24), e017759. [More Information]
Cosorich, I., McGuire, H., Warren, J., Danta, M., King, C. (2019). CCR9 Expressing T Helper and T Follicular Helper Cells Exhibit Site-Specific Identities During Inflammatory Disease. Frontiers in Immunology, 9(2899), 1-15. [More Information]
Russo, M., Fiore, N., Van Vreden, C., Bailey, D., Santarelli, D., McGuire, H., Fazekas de St Groth, B., Austin, P. (2019). Correction to: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. Journal of Neuroinflammation, 16(1), 1-2. [More Information]
Gide, T., Quek, C., Menzies, A., Tasker, A., Shang, P., Holst, J., Madore, J., Lim, S., Wongchenko, M., Lo, S., Carlino, M., Guminski, A., Saw, R., Pang, A., McGuire, H., Palendira, M., Thompson, J., Rizos, H., Da Silva, I., Batten, M., Scolyer, R., Long, G., Wilmott, J., et al (2019). Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy. Cancer Cell, 35(2), 238-255.e6. [More Information]
Russo, M., Fiore, N., Van Vreden, C., Bailey, D., Santarelli, D., McGuire, H., Fazekas de St Groth, B., Austin, P. (2019). Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. Journal of Neuroinflammation, 16(1), 1-17. [More Information]
Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W., Aghaeepour, N., Akdis, M., Allez, M., McGuire, H., Ng, L., et al (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European Journal of Immunology, 49(10), 1457-1973. [More Information]
Norton, S., Ward-Hartstonge, K., McCall, J., Leman, J., Taylor, E., Munro, F., Black, M., Fazekas de St Groth, B., McGuire, H., Kemp, R. (2019). High-Dimensional Mass Cytometric Analysis Reveals an Increase in Effector Regulatory T Cells as a Distinguishing Feature of Colorectal Tumors. Journal of Immunology, 202(6), 1871-1884. [More Information]
Marsh-Wakefield, F., Kruzins, A., McGuire, H., Yang, S., Bryant, C., Fazekas de St Groth, B., Nassif, N., Byrne, S., Gibson, J., Brown, C., Larsen, S., McCulloch, D., Joshua, D., Ho, P., et al (2019). Mass Cytometry Discovers Two Discrete Subsets of CD39-Treg Which Discriminate MGUS From Multiple Myeloma. Frontiers in Immunology, 10, 1-12. [More Information]
Shinko, D., McGuire, H., Diakos, C., Pavlakis, N., Clarke, S., Byrne, S., Charles (nee Slaviero), K. (2019). Mass Cytometry Reveals a Sustained Reduction in CD16+ Natural Killer Cells Following Chemotherapy in Colorectal Cancer Patients. Frontiers in Immunology, 10, 1-12. [More Information]
Aghajani, M., Cooper, A., McGuire, H., Jeffries, T., Saab, J., Ismail, K., de Souza, P., Bray, V., Fazekas de St Groth, B., Niles, N., et al (2019). Pembrolizumab for anaplastic thyroid cancer: a case study. Cancer Immunology, Immunotherapy, 68(12), 1921-1934. [More Information]
Shinko, D., Ashhurst, T., McGuire, H., Charles, K. (2019). Staining of Phosphorylated Signalling Markers Protocol for Mass Cytometry. Methods in Molecular Biology, 1989, 139-139. [More Information]
Lepletier, A., Lutzky, V., Mittal, D., Stannard, K., Watkins, T., Ratnatunga, C., Smith, C., McGuire, H., Kemp, R., Mukhopadhyay, P., et al (2019). The immune checkpoint CD96 defines a distinct lymphocyte phenotype & is highly expressed on tumor-infiltrating T cells. Immunology and Cell Biology, 97(2), 152-164. [More Information]
Van Vreden, C., Niewold, P., McGuire, H., Fazekas de St Groth, B. (2019). Titration of Mass Cytometry Reagents. Methods in Molecular Biology, 1989, 83-92. [More Information]
Mulcahy, E., Cooley, M., McGuire, H., Asad, S., Fazekas de St Groth, B., Beggs, S., Roddam, L. (2019). Widespread alterations in the peripheral blood innate immune cell profile in cystic fibrosis reflect lung pathology. Immunology and Cell Biology, 97(4), 416-426. [More Information]
Hsu, J., Bryant, C., Papadimitrious, M., Kong, B., Gasiorowski, R., Orellana, D., McGuire, H., Fazekas de St Groth, B., Joshua, D., Ho, P., Iland, H., Gibson, J., Clark, G., Fromm, P., Hart, D., et al (2018). A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission. OncoImmunology, 7(4), e1419114-1-e1419114-11. [More Information]
McGuire, H., Shklovskaya, E., Edwards, J., Trevillian, P., McCaughan, G., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S., Fazekas de St Groth, B., Hersey, P. (2018). Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report. Cancer Immunology, Immunotherapy, 67(4), 563-573. [More Information]
Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]
McGuire, H., Watkins, T., Field, M., Taylor, S., Yasuyama, N., Farmer, A., Miles, J., Fazekas de St Groth, B. (2018). TCR deep sequencing of transgenic RAG-1-deficient mice reveals endogenous TCR recombination: a cause for caution. Immunology and Cell Biology, 96(6), 642-645. [More Information]
Lomax, A., McGuire, H., McNeil, C., Choi, C., Hersey, P., Karikios, D., Shannon, K., Van Hal, S., Carr, U., Crotty, A., Hollingsworth, J., Kim, H., Fazekas de St Groth, B., McGill, N., et al (2017). Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis. International Journal of Rheumatic Diseases, 20(9), 1277-1285. [More Information]
Guy, T., Terry, A., Bolton, H., Hancock, D., Zhu, E., Brink, R., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2016). Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Oncotarget, 7(21), 30211-30229. [More Information]
Havenar-Daughton, C., Lindqvist, M., Heit, A., Wu, J., Reiss, S., Kendric, K., Belanger, S., Kasturi, S., Landais, E., Akondy, R., et al (2016). CXCL13 is a plasma biomarker of germinal center activity. Proceedings of the National Academy of Sciences of the United States of America, 113(10), 2702-2707. [More Information]
Rubelt, F., Bolen, C., McGuire, H., Vander Heiden, J., Gadala-Maria, D., Levin, M., Euskirchen, G., Mamedov, M., Swan, G., Dekker, C., et al (2016). Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells. Nature Communications, 7, 1-12. [More Information]
Withani, N., Ma, X., McGuire, H., Verdoes, M., van der Linden, W., Ofori, L., Zhang, R., Li, H., Sanman, L., Wei, K., et al (2016). Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Scientific Reports, 6, 1-10. [More Information]
McGuire, H., Vogelzang, A., Warren, J., Loetsch, C., Natividad, K., Chan, T., Brink, R., Batten, M., King, C. (2015). IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses. Journal of Immunology, 195(11), 5123-5135. [More Information]
Andres-Terre, M., McGuire, H., Pouliot, Y., Bongen, E., Sweeney, T., Tato, C., Khatri, P. (2015). Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses. Immunity, 43(6), 1199-1211. [More Information]
Vogelzang, A., McGuire, H., Liu, S., Gloss, B., Mercado, K., Earls, P., Dinger, M., Batten, M., Sprent, J., King, C. (2014). IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. Journal of Immunology, 192(4), 1404-1414. [More Information]
Su, L., Han, A., McGuire, H., Furman, D., Newell, E., Davis, M. (2013). The Promised Land of Human Immunology. Cold Spring Harbor Laboratory Symposia on Quantitative Biology, 78(1), 203-213. [More Information]
McGuire, H., Vogelzang, A., Ma, C., Hughes, W., Silveira, P., Tangye, S., Christ, D., Fulcher, D., Falcone, M., King, C. (2011). A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity, 34(4), 602-615. [More Information]
McGuire, H., Walters, S., Vogelzang, A., Lee, C., Webster, K., Sprent, J., Christ, D., Grey, S., King, C. (2011). Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models. Diabetes, 60(3), 867-875. [More Information]
Lee, C., McGuire, H., Basten, A., King, C., Christ, D. (2010). Expression, purification and characterization of recombinant interleukin-21. Journal of Immunological Methods, 362(1-2), 185-189. [More Information]
McGuire, H., Vogelzang, A., Hill, N., Flodstrom-Tulllberg, M., Sprent, J., King, C. (2009). Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proceedings of the National Academy of Sciences of the United States of America, 106(46), 19438-19443. [More Information]
Akerfeldt, M., Howes, J., Chan, J., Stevens, V., McGuire, H., Boubenna, N., King, C., Biden, T., Laybutt, D. (2008). Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes, 57(11), 3034-3044. [More Information]

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2025

Huang, C., Siwan, E., Baker, C., Wei, Z., Shinko, D., McGuire, H., Twigg, S., Min, D. (2025). Uncovering Sex-Related Differences in Skin Macrophage Polarization During Wound Healing in Diabetic Mice. Frontiers in Bioscience - Landmark, 30(2), 27113. [More Information]

2024

Tseng, H., Alavi, S., Gallagher, S., McGuire, H., Hersey, P., Emran, A., Tiffen, J. (2024). BET inhibition sensitizes innate checkpoint inhibitor resistant melanoma to anti-CTLA-4 treatment. Pigment Cell & Melanoma Research. [More Information]
Zhang, Z., Yang, H., Eshraghian, J., Li, J., Yong, K., Vigolo, D., McGuire, H., Kavehei, O. (2024). Cell detection with convolutional spiking neural network for neuromorphic cytometry. APL Machine Learning, 2, 026117-1-026117-8. [More Information]
Budden, K., Faiz, A., Patel, V., Donovan, C., Alemao, C., Shen, S., Amorim, N., Majumder, R., Vanka, K., Mason, J., Ashhurst, T., Van Vreden, C., McGuire, H., Fazekas de St Groth, B., King, N., Crossett, B., Cordwell, S., et al (2024). Faecal microbial transfer and complex carbohydrates mediate protection against COPD. Gut, 73(5), 751-769. [More Information]
Bate, K., Genetzakis, E., Vescovi, J., Gray, M., Celermajer, D., McGuire, H., Grieve, S., Vernon, S., Cartland, S., Yang, J., Kavurma, M., Figtree, G. (2024). Vascular Cytokines and Atherosclerosis: Differential Serum Levels of TRAIL, IL-18, and OPG in Obstructive Coronary Artery Disease. Biomolecules, 14, 1119. [More Information]

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2023

Smith, N., Maddahfar, M., Gunasegaran, B., McGuire, H., Fazekas de St Groth, B. (2023). A High-Throughput Colorimetric Microplate Assay for Determination of Plasma Arginase Activity. In Anna S. Kashina (Eds.), Protein Arginylation - Methods and Protocols, (pp. 273-286). United States: Humana Press. [More Information]
Louie, R., Cai, C., Samir, J., Singh, M., Deveson, I., Ferguson, J., Amos, T., McGuire, H., Gowrishankar, K., Adikari, T., Bishop, D., Gottlieb, D., Blyth, E., Micklethwaite, K., et al (2023). CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies. Nature Communications, 14(1). [More Information]
Stern, L., McGuire, H., Avdic, S., Blyth, E., Gottlieb, D., Patrick, E., Abendroth, A., Slobedman, B. (2023). Circulating cytokine and chemokine patterns associated with cytomegalovirus reactivation after stem cell transplantation. Clinical & Translational Immunology, 12(12), e16815-1-e16815-17. [More Information]
Kott, K., Chan, A., Vernon, S., Hansen, T., Kim, T., De Dreu, M., Gunasegaran, B., Murphy, A., Patrick, E., Psaltis, P., Grieve, S., Yang, J., Fazekas de St Groth, B., McGuire, H., Figtree, G. (2023). Mass cytometry analysis reveals altered immune profiles in patients with coronary artery disease. Clinical & Translational Immunology, 12(11), e1462-1-e1462-18. [More Information]
Guy, T., Terry, A., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2023). MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo. OncoImmunology, 13(1), 2290799. [More Information]
Su, Z., Diao, T., McGuire, H., Yao, C., Yang, L., Bao, G., Xu, X., He, B., Zheng, Y. (2023). Nanomaterials Solutions for Contraception: Concerns, Advances, and Prospects. ACS Nano, 17(21), 20753-20775. [More Information]
Zhang, Z., Xu, Z., McGuire, H., Essam, C., Nicholson, A., Hamilton, T., Li, J., Eshraghian, J., Yong, K., Vigolo, D., Kavehei, O. (2023). Neuromorphic cytometry: implementation on cell counting and size estimation. Neuromorphic Computing and Engineering, 3(4), 044005. [More Information]
Rose, C., McGuire, H., Graham, K., Siegler, J., Fazekas de St Groth, B., Caillaud, C., Edwards, K. (2023). Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings. European Journal of Applied Physiology, 123(2), 407-415. [More Information]
Jiang, W., Avdic, S., Lee, K., Street, J., Castellano-Gonzalez, G., Simms, R., Clancy, L., Blennerhassett, R., Patrick, E., Chan, A., McGuire, H., Myers, N., Gloss, B., Bateman, C., Micklethwaite, K., Gottlieb, D., Blyth, E., et al (2023). Persistence of ex vivo expanded tumour and pathogen specific T-cells after allogeneic stem cell transplant for myeloid malignancies (the INTACT study). Leukemia, 37(11), 2330-2333. [More Information]
Kott, K., Genetzakis, E., Gray, M., Hansen, P., McGuire, H., Yang, J., Grieve, S., Vernon, S., Figtree, G. (2023). Serum Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 (sLOX-1) Is Associated with Atherosclerosis Severity in Coronary Artery Disease. Biomolecules, 13(8), 1187-17 pages. [More Information]

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2022

Hey-Cunningham, A., Riaz, A., Fromm, P., Kupresanin, F., Markham, R., McGuire, H. (2022). Circulating and Endometrial Regulatory T Cell and Related Populations in Endometriosis and Infertility: Endometriosis Is Associated with Blunting of Endometrial Cyclical Effects and Reduced Proportions in Moderate-Severe Disease. Reproductive Sciences, 29(1), 229-242. [More Information]
Figtree, G., Kovacic, J., McGuire, H. (2022). Human susceptibility to coronary artery disease: lessons from chimpanzee resilience. Nature Reviews Cardiology, 19(8), 497-498. [More Information]
Stern, L., McGuire, H., Avdic, S., Fazekas de St Groth, B., Gottlieb, D., Abendroth, A., Blyth, E., Slobedman, B. (2022). Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation. Nature Communications, 13(1), 2603. [More Information]
Bell, K., Saad, S., Tillett, B., McGuire, H., Bordbar, S., Yap, Y., Nguyen, L., Wilkins, M., Corley, S., Brodie, S., Duong, S., Wright, C., Twigg, S., Fazekas de St Groth, B., et al (2022). Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation. Microbiome, 10(1). [More Information]
Alavi, S., Emran, A., Tseng, H., Tiffen, J., McGuire, H., Hersey, P. (2022). Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T Cells. Cancers, 14(2), 323. [More Information]
Marsh-Wakefield, F., Juillard, P., Ashhurst, T., Juillard, A., Shinko, D., Putri, G., Read, M., McGuire, H., Byrne, S., Hawke, S., Grau, G. (2022). Peripheral B-cell dysregulation is associated with relapse after long-term quiescence in patients with multiple sclerosis. Immunology and Cell Biology, 100(6), 453-467. [More Information]
Jiang, W., Clancy, L., Avdic, S., Sutrave, G., Street, J., Simms, R., McGuire, H., Patrick, E., Chan, A., McCaughan, G., Myers, N., Micklethwaite, K., Bateman, C., Shaw, P., Blyth, E., Gottlieb, D., et al (2022). Third-party CMV- and EBV-specific T-cells for first viral reactivation after allogeneic stem cell transplant. Blood Advances, 6(17), 4949-4966. [More Information]

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2021

Seddiki, N., Zaunders, J., Phetsouphanh, C., Brezar, V., Xu, Y., McGuire, H., Bailey, M., McBride, K., Hey-Cunningham, W., Munier, C., Fazekas de St Groth, B., et al (2021). CD73+ CD127high long-term memory CD4 T cells are highly proliferative in response to recall antigens and are early targets in hiv-1 infection. International Journal of Molecular Sciences, 22(2), 1-28. [More Information]
Hey-Cunningham, A., Wong, C., Hsu, J., Fromm, P., Clark, G., Kupresanin, F., Miller, E., Markham, R., McGuire, H. (2021). Comprehensive analysis utilizing flow cytometry and immunohistochemistry reveals inflammatory changes in local endometrial and systemic dendritic cell populations in endometriosis. Human Reproduction, 36(2), 415-428. [More Information]
Bishop, D., Clancy, L., Simms, R., Burgess, J., Mathew, G., Moezzi, L., Street, J., Sutrave, G., Atkins, E., McGuire, H., Lee, K., Jiang, W., McCaughan, G., Shaw, P., Gottlieb, D., Blyth, E., Micklethwaite, K., et al (2021). Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells. Blood, 138(16), 1504-1509. [More Information]
Jerram, A., Guy, T., Beutler, L., Gunasegaran, B., Sluyter, R., Fazekas de St Groth, B., McGuire, H. (2021). Effects of storage time and temperature on highly multiparametric flow analysis of peripheral blood samples; implications for clinical trial samples. Bioscience Reports, 41(2), BSR20203827. [More Information]
Marsh-Wakefield, F., Mitchell, A., Norton, S., Ashhurst, T., Leman, J., Roberts, J., Harte, J., McGuire, H., Kemp, R. (2021). Making the most of high-dimensional cytometry data. Immunology and Cell Biology, 99(7), 680-696. [More Information]
Gottlieb, D., Clancy, L., Withers, B., McGuire, H., Luciani, F., Singh, M., Hughes, B., Gloss, B., Kliman, D., Ma, C., Bishop, D., Dubosq, M., Li, Z., Avdic, S., Micklethwaite, K., Blyth, E., et al (2021). Prophylactic antigen-specific T-cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant. Clinical & Translational Immunology, 10(3), e1249. [More Information]
O'Brien, J., McGuire, H., Shinko, D., Fazekas de St Groth, B., Russo, M., Bailey, D., Santarelli, D., Wynne, K., Austin, P. (2021). T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain. Brain, Behavior, & Immunity - Health, 15, 100283. [More Information]

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2020

Norton, S., Leman, J., Khong, T., Spencer, A., Fazekas de St Groth, B., McGuire, H., Kemp, R. (2020). Brick plots: An intuitive platform for visualizing multiparametric immunophenotyped cell clusters. BMC Bioinformatics, 21(1), 145. [More Information]
Johnson, B., McAlister, S., McGuire, H., Palanivelu, V., Stevenson, A., Richmond, P., Palmer, D., Metcalfe, J., Prescott, S., Wood, F., Fazekas de St Groth, B., et al (2020). Corrigendum: Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response. Frontiers in Immunology, 11, 598646. [More Information]
Fromm, P., Silveira, P., Hsu, J., Papadimitrious, M., Lo, T., Ju, X., Kupresanin, F., Romano, A., Hsu, W., Bryant, C., Kong, B., Abadir, E., McGuire, H., Fazekas de St Groth, B., Hart, D., Clark, G., et al (2020). Distinguishing human peripheral blood CD16+ myeloid cells based on phenotypic characteristics. Journal of Leukocyte Biology, 107(2), 323-339. [More Information]
Emran, A., Tseng, H., Coleman, M., Tiffen, J., Cook, S., McGuire, H., Gallagher, S., Feng, C., Hersey, P. (2020). Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma? Pigment Cell & Melanoma Research, 33(5), 660-670. [More Information]
Lee, K., Gowrishankar, K., Street, J., McGuire, H., Luciani, F., Hughes, B., Singh, M., Clancy, L., Gottlieb, D., Micklethwaite, K., Blyth, E. (2020). Ex vivo enrichment of PRAME antigen-specific T cells for adoptive immunotherapy using CD137 activation marker selection. Clinical & Translational Immunology, 9(e1200), 1-13. [More Information]
Marsh-Wakefield, F., Ashhurst, T., Trend, S., McGuire, H., Juillard, P., Zinger, A., Jones, A., Kermode, A., Hawke, S., Grau, G., Byrne, S., et al (2020). IgG3+ B cells are associated with the development of multiple sclerosis. Clinical & Translational Immunology, 9(5), 1-13. [More Information]
Larsen, B., Cox, A., Colbey, C., Drew, M., McGuire, H., Fazekas de St Groth, B., Hughes, D., Vlahovich, N., Waddington, G., Burke, L., et al (2020). Inflammation and Oral Contraceptive Use in Female Athletes Before the Rio Olympic Games. Frontiers in Physiology, 11, 497. [More Information]
Vuckovic, S., Bryant, C., Lau, K., Yang, S., Favaloro, J., McGuire, H., Clark, G., Fazekas de St Groth, B., Marsh-Wakefield, F., Nassif, N., McCulloch, D., Brown, C., Larsen, S., Gibson, J., Joshua, D., Ho, P., et al (2020). Inverse relationship between oligoclonal expanded CD69- TTE and CD69+ TTE cells in bone marrow of multiple myeloma patients. Blood Advances, 4(19), 4593-4604. [More Information]
Zaunders, J., Munier, C., McGuire, H., Law, H., Howe, A., Xu, Y., Fazekas de St Groth, B., Schofield, P., Christ, D., Milner, B., Dyer, W., et al (2020). Mapping the extent of heterogeneity of human CCR5(+)CD4(+)T cells in peripheral blood and lymph node. AIDS, 34(6), 833-848. [More Information]
McGuire, H., Rizzetto, S., Withers, B., Clancy, L., Avdic, S., Stern, L., Patrick, E., Fazekas de St Groth, B., Slobedman, B., Gottlieb, D., Blyth, E., et al (2020). Mass cytometry reveals immune signatures associated with cytomegalovirus (CMV) control in recipients of allogeneic haemopoietic stem cell transplant and CMV-specific T cells. Clinical & Translational Immunology, 9(7), 1-16. [More Information]
Johnson, B., McAlister, S., McGuire, H., Palanivelu, V., Stevenson, A., Richmond, P., Palmer, D., Metcalfe, J., Prescott, S., Wood, F., Fazekas de St Groth, B., et al (2020). Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response. Frontiers in Immunology, 11, 1-15. [More Information]
Pirozyan, M., McGuire, H., Emran, A., Tseng, H., Tiffen, J., Lee, J., Carlino, M., Menzies, A., Long, G., Scolyer, R., Fazekas de St Groth, B., Hersey, P. (2020). Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients. Frontiers in Immunology, 11, 372. [More Information]
Castellano-González, G., McGuire, H., Luciani, F., Clancy, L., Li, Z., Avdic, S., Hughes, B., Singh, M., Fazekas de St Groth, B., Renga, G., Gottlieb, D., et al (2020). Rapidly expanded partially HLA DRB1-matched fungus-specific T cells mediate in vitro and in vivo antifungal activity. Blood Advances, 4(14), 3443-3456. [More Information]
Kott, K., Vernon, S., Hansen, T., De Dreu, M., Das, S., Powell, J., Fazekas de St Groth, B., Di Bartolo, B., McGuire, H., Figtree, G. (2020). Single-Cell Immune Profiling in Coronary Artery Disease: The Role of State-of-the-Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis. Journal of the American Heart Association, 9(24), e017759. [More Information]

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2019

Cosorich, I., McGuire, H., Warren, J., Danta, M., King, C. (2019). CCR9 Expressing T Helper and T Follicular Helper Cells Exhibit Site-Specific Identities During Inflammatory Disease. Frontiers in Immunology, 9(2899), 1-15. [More Information]
Russo, M., Fiore, N., Van Vreden, C., Bailey, D., Santarelli, D., McGuire, H., Fazekas de St Groth, B., Austin, P. (2019). Correction to: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. Journal of Neuroinflammation, 16(1), 1-2. [More Information]
Gide, T., Quek, C., Menzies, A., Tasker, A., Shang, P., Holst, J., Madore, J., Lim, S., Wongchenko, M., Lo, S., Carlino, M., Guminski, A., Saw, R., Pang, A., McGuire, H., Palendira, M., Thompson, J., Rizos, H., Da Silva, I., Batten, M., Scolyer, R., Long, G., Wilmott, J., et al (2019). Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy. Cancer Cell, 35(2), 238-255.e6. [More Information]
Russo, M., Fiore, N., Van Vreden, C., Bailey, D., Santarelli, D., McGuire, H., Fazekas de St Groth, B., Austin, P. (2019). Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. Journal of Neuroinflammation, 16(1), 1-17. [More Information]
Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W., Aghaeepour, N., Akdis, M., Allez, M., McGuire, H., Ng, L., et al (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European Journal of Immunology, 49(10), 1457-1973. [More Information]
Norton, S., Ward-Hartstonge, K., McCall, J., Leman, J., Taylor, E., Munro, F., Black, M., Fazekas de St Groth, B., McGuire, H., Kemp, R. (2019). High-Dimensional Mass Cytometric Analysis Reveals an Increase in Effector Regulatory T Cells as a Distinguishing Feature of Colorectal Tumors. Journal of Immunology, 202(6), 1871-1884. [More Information]
Marsh-Wakefield, F., Kruzins, A., McGuire, H., Yang, S., Bryant, C., Fazekas de St Groth, B., Nassif, N., Byrne, S., Gibson, J., Brown, C., Larsen, S., McCulloch, D., Joshua, D., Ho, P., et al (2019). Mass Cytometry Discovers Two Discrete Subsets of CD39-Treg Which Discriminate MGUS From Multiple Myeloma. Frontiers in Immunology, 10, 1-12. [More Information]
Shinko, D., McGuire, H., Diakos, C., Pavlakis, N., Clarke, S., Byrne, S., Charles (nee Slaviero), K. (2019). Mass Cytometry Reveals a Sustained Reduction in CD16+ Natural Killer Cells Following Chemotherapy in Colorectal Cancer Patients. Frontiers in Immunology, 10, 1-12. [More Information]
Aghajani, M., Cooper, A., McGuire, H., Jeffries, T., Saab, J., Ismail, K., de Souza, P., Bray, V., Fazekas de St Groth, B., Niles, N., et al (2019). Pembrolizumab for anaplastic thyroid cancer: a case study. Cancer Immunology, Immunotherapy, 68(12), 1921-1934. [More Information]
Shinko, D., Ashhurst, T., McGuire, H., Charles, K. (2019). Staining of Phosphorylated Signalling Markers Protocol for Mass Cytometry. Methods in Molecular Biology, 1989, 139-139. [More Information]
Lepletier, A., Lutzky, V., Mittal, D., Stannard, K., Watkins, T., Ratnatunga, C., Smith, C., McGuire, H., Kemp, R., Mukhopadhyay, P., et al (2019). The immune checkpoint CD96 defines a distinct lymphocyte phenotype & is highly expressed on tumor-infiltrating T cells. Immunology and Cell Biology, 97(2), 152-164. [More Information]
Van Vreden, C., Niewold, P., McGuire, H., Fazekas de St Groth, B. (2019). Titration of Mass Cytometry Reagents. Methods in Molecular Biology, 1989, 83-92. [More Information]
Mulcahy, E., Cooley, M., McGuire, H., Asad, S., Fazekas de St Groth, B., Beggs, S., Roddam, L. (2019). Widespread alterations in the peripheral blood innate immune cell profile in cystic fibrosis reflect lung pathology. Immunology and Cell Biology, 97(4), 416-426. [More Information]

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2018

Hsu, J., Bryant, C., Papadimitrious, M., Kong, B., Gasiorowski, R., Orellana, D., McGuire, H., Fazekas de St Groth, B., Joshua, D., Ho, P., Iland, H., Gibson, J., Clark, G., Fromm, P., Hart, D., et al (2018). A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission. OncoImmunology, 7(4), e1419114-1-e1419114-11. [More Information]
McGuire, H., Shklovskaya, E., Edwards, J., Trevillian, P., McCaughan, G., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S., Fazekas de St Groth, B., Hersey, P. (2018). Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report. Cancer Immunology, Immunotherapy, 67(4), 563-573. [More Information]
Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]
McGuire, H., Watkins, T., Field, M., Taylor, S., Yasuyama, N., Farmer, A., Miles, J., Fazekas de St Groth, B. (2018). TCR deep sequencing of transgenic RAG-1-deficient mice reveals endogenous TCR recombination: a cause for caution. Immunology and Cell Biology, 96(6), 642-645. [More Information]

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2017

Lomax, A., McGuire, H., McNeil, C., Choi, C., Hersey, P., Karikios, D., Shannon, K., Van Hal, S., Carr, U., Crotty, A., Hollingsworth, J., Kim, H., Fazekas de St Groth, B., McGill, N., et al (2017). Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis. International Journal of Rheumatic Diseases, 20(9), 1277-1285. [More Information]

2016

Guy, T., Terry, A., Bolton, H., Hancock, D., Zhu, E., Brink, R., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2016). Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Oncotarget, 7(21), 30211-30229. [More Information]
Havenar-Daughton, C., Lindqvist, M., Heit, A., Wu, J., Reiss, S., Kendric, K., Belanger, S., Kasturi, S., Landais, E., Akondy, R., et al (2016). CXCL13 is a plasma biomarker of germinal center activity. Proceedings of the National Academy of Sciences of the United States of America, 113(10), 2702-2707. [More Information]
Rubelt, F., Bolen, C., McGuire, H., Vander Heiden, J., Gadala-Maria, D., Levin, M., Euskirchen, G., Mamedov, M., Swan, G., Dekker, C., et al (2016). Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells. Nature Communications, 7, 1-12. [More Information]
Withani, N., Ma, X., McGuire, H., Verdoes, M., van der Linden, W., Ofori, L., Zhang, R., Li, H., Sanman, L., Wei, K., et al (2016). Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Scientific Reports, 6, 1-10. [More Information]

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2015

McGuire, H., Vogelzang, A., Warren, J., Loetsch, C., Natividad, K., Chan, T., Brink, R., Batten, M., King, C. (2015). IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses. Journal of Immunology, 195(11), 5123-5135. [More Information]
Andres-Terre, M., McGuire, H., Pouliot, Y., Bongen, E., Sweeney, T., Tato, C., Khatri, P. (2015). Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses. Immunity, 43(6), 1199-1211. [More Information]

2014

Vogelzang, A., McGuire, H., Liu, S., Gloss, B., Mercado, K., Earls, P., Dinger, M., Batten, M., Sprent, J., King, C. (2014). IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. Journal of Immunology, 192(4), 1404-1414. [More Information]
King, C., McGuire, H. (2014). The Immunobiology of Interleukin-21. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 496-506). New York: Springer Science+Business Media.

2013

Su, L., Han, A., McGuire, H., Furman, D., Newell, E., Davis, M. (2013). The Promised Land of Human Immunology. Cold Spring Harbor Laboratory Symposia on Quantitative Biology, 78(1), 203-213. [More Information]

2011

McGuire, H., Vogelzang, A., Ma, C., Hughes, W., Silveira, P., Tangye, S., Christ, D., Fulcher, D., Falcone, M., King, C. (2011). A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity, 34(4), 602-615. [More Information]
McGuire, H., Walters, S., Vogelzang, A., Lee, C., Webster, K., Sprent, J., Christ, D., Grey, S., King, C. (2011). Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models. Diabetes, 60(3), 867-875. [More Information]

2010

Lee, C., McGuire, H., Basten, A., King, C., Christ, D. (2010). Expression, purification and characterization of recombinant interleukin-21. Journal of Immunological Methods, 362(1-2), 185-189. [More Information]

2009

McGuire, H., Vogelzang, A., Hill, N., Flodstrom-Tulllberg, M., Sprent, J., King, C. (2009). Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proceedings of the National Academy of Sciences of the United States of America, 106(46), 19438-19443. [More Information]

2008

Akerfeldt, M., Howes, J., Chan, J., Stevens, V., McGuire, H., Boubenna, N., King, C., Biden, T., Laybutt, D. (2008). Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes, 57(11), 3034-3044. [More Information]

Selected Grants

2024

Forecasting Nano-3D Biointegration, Holmes N, Cairney J, McGuire H, Roohani I, Nano Institute/Kickstarter

2023

Dissecting the susceptibility of humans to coronary artery disease (CAD), Tang O, McGuire H, Figtree G, Patrick E, Gray M, Heart Research Australia/Research Grant
Improving early diagnosis and treatment of CAD- above and beyond standard modifiable risk factors (SMuRFs), Figtree G, Xiang M, Yang J, Grieve S, Cordwell S, McGuire H, Vernon S, Office of Global and Research Engagement/Ignition Grants
USYD-Glasgow Biomedical Engineering Alliance: Revolutionising Cancer Immunotherapy with Triboelectric Nanogenerator (TENG)-Based Sensor Systems and zMovi High-throughput Cell Avidity Analyser Platform, Ju A, Jing Q, Rasko J, Vassali M, Van Oijen A, Mulvihill D, McGuire H, Li G, Wang Y, He Z, Yeo D, Silavnieks U, Office of Global and Research Engagement/Ignition Grants

2022

Early Career Women in STEMM Grant and Article Writing Workshop (ECWW2023), Holmes N, Xu X, McGuire H, Li Z, Cairney J, Office of the NSW Chief Scientist & Engineer/Conference Sponsorship Program
Dissecting the susceptibility of humans to coronary artery disease (CAD), Ng H, McGuire H, Figtree G, Patrick E, Gray M, Heart Research Australia/Research Grant
Immunoprofiling of high-risk paediatric cancer, McGuire H, Childrens Cancer Institute Australia/Research Grant
Early to Mid-Career Researcher Professional Development, McGuire H, Charles Perkins Centre/Early to Mid-Career Researcher Professional Development

2021

Development of a novel blood test that accurately predicts response to checkpoint therapy in cancer patients, Fazekas de St Groth B, Tsonis C, McGuire H, Vafaee F, Boyer M, Kao S, Lee J, Rankin N, National Health and Medical Research Council (NHMRC)/Development Grants
New Frontiers in Personalised Prevention of Coronary Artery Disease, Figtree G, Celemajer D, Chow C, Fazekas de St Groth B, Drummond G, Ellinor P, Grieve S, Jenkins A, Kassiou M, Keech A, Kovacic J, Larance M, Marwick T, McGuire H, Meikle P, Nicholls S, O'Sullivan J, Peter K, Ritchie R, Shaw J, Simes R, Walley T, Wilson A, Department of Health and Aged Care (Federal)/MRFF - Frontier Health and Medical Research Program, Stage One

2020

Unravelling the calcification-inflammation axis to predict the risk of heart disease, Figtree G, Di Bartolo B, McGuire H, Heart Research Australia/Research Grant

2018

RES: Prediabetics CyTOF Project - The New Zealand Institute for Plant and Food Research Limited PFR - Helen McGuire, McGuire H, New Zealand Institute For Plant and Food Research Ltd/Client Commissioned Research
Cardiovascular Precision Medicine and Biomarker Development: Analysis of how underlying inflammatory status dictates susceptibility or resilience to coronary artery disease , McGuire H, Cardiovascular Initiative/Catalyst Awards for Seed Funding in Precision Medicine
Epigenetic targeting of T cell dysfunction "exhaustion" in patients failing treatment with immune checkpoint inhibitors, Hersey P, McGuire H, Shklovskaya E, Gallagher S, Carlino M, Cancer Council NSW/Research Grant

2017

Regulatory T cell therapy for prevention of graft versus host disease, Fazekas de St Groth B, Hart D, Bolton H, McGuire H, National Health and Medical Research Council (NHMRC)/Project Grants
Systems analysis for defining the biological effect of advanced cell therapies in haematooncology, McGuire H, Sydney Medical School/Kickstart Grant
SMS ECR Overseas Conference Support - McGuire, McGuire H, Sydney Medical School/Early Career Researcher Overseas Travel Grant
Development of a novel test to predict clinical response to checkpoint therapy in lung cancer and mesothelioma., McGuire H, University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding
Setting up for health or disease: Understanding how the 'Immune-Rheostat' is tuned in early life, McGuire H, Lifespan Research Network/Lifespan Seed Grants Program

2015

The Sydney 1000 Cancer Project â€“ Stage 1 Gastrointestinal Cancers Immunophenotyping Study, Charles (nee Slaviero) K, Clarke S, Diakos C, Pavlakis N, Engel A, Samra J, Gill A, Kneebone A, Fazekas de St Groth B, Hart D, Smith A, Byrne S, McGuire H, Vafaee F, King M, DVC Research/SPARC Implementation - Cancer

2014

Contained reactivity in the immune system, McGuire H, National Health and Medical Research Council (NHMRC)/Early Career Fellowships

Additional Publications

Vogelzang,H.M. McGuire, S.M. Liu, B. Gloss, K. Mercado, P. Earls, M.E. Dinger, M. Batten, J. Sprent, C. KingIL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells Journal of Immunology (2014) 1921404 - 1414

H.M. McGuire, C. KingThe Immunobiology of Interleukin-21 I.R. Mackay, N.R. Rose (eds.) Encyclopedia of MedicalImmunology (2014) Chapter 204

L.F. Su, A. Han, H.M. McGuire, D. Furman, E.W. Newell, M.M. Davis The promised land of human immunology Cold Spring Harb. Symp. Quant. Biol. (2013) 78 203-13

H.M. McGuire, A. Vogelzang, C.S. Ma, W.E. Hughes, P. Silviera, S.G. Tangye, D. Christ, D. Fulcher, M. Falcone, C. KingA subset of interleukin-21+chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system for autoimmunity Immunity(2011) 344

H.M. McGuire, S. Walters, A. Vogelzang, C.M.Y. Lee, K.E. Webster, J. Sprent, D. Christ, S.T. Grey, C. KingInterleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models Diabetes (2011) 603 867-75

C.M. Lee, H.M. McGuire, A. Basten, C. King, D. Christ Expression, purification and characterization of recombinant interleukin-21 Journal of Immunol Methods (2010) 3621-2 185-9

H.M. McGuire, A. Vogelzang, N. Hill, M. Flodström-Tullberg, J. Sprent, C. KingLoss of parity between il2 and il21in the NOD Idd3 locus Proc Natl Acad Sci (2009) 10646 19438 - 19443

M.C. Akerfeldt, J. Howes, J.Y. Chan, V.A. Stevens, N. Boubenna, H.M. McGuire, C. King, T.J. Biden, D.R. LaybuttCytokine-induced beta cell death is independent of endoplasmic reticulum stress signaling Diabetes(2008) 5711 3034 – 3044

A. Vogelzang, H.M. McGuire, D. Yu, J. Sprent, C. Mackay, C. KingA fundamental role for Interleukin-21 in the generation of T follicular helper cells Immunity (2008) 291 127 - 137

Faculty of Medicine and Health

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