People_

Dr Philip Kwok

BPharm(Hons), PhD, GradCertEdStud (Higher Ed), FHEA, JP

Senior Lecturer in Pharmaceutical Sciences
Research Education Academic Director (READ), Central Sydney (Patyegarang) Precinct
FungiSphere Therapeutics and Global Health Systems Theme Leader
Sydney Infectious Diseases Institute (Sydney ID)

Phone

+61 2 8627 6456

Fax

+61 2 9351 4391

Email

[email protected]

Details

Member of The Centre for Drug Discovery Innovation

Websites

ORCID 0000-0002-5362-0671

Resume

Dr Philip Chi Lip Kwok is a Senior Lecturer in Pharmaceutical Sciences in the School of Pharmacy, The University of Sydney. He obtained his Bachelor of Pharmacy degree with First Class Honours in 2002 from this Faculty. He became a registered pharmacist after one year of training in a community pharmacy. Dr Kwok then undertook his PhD studies on pharmaceutical aerosol electrostatics in the Faculty of Pharmacy at The University of Sydney and graduated in 2007. He was a research associate in the same group until August 2011 and became an assistant professor in the Department of Pharmacology and Pharmacy at The University of Hong Kong in September 2011. Dr Kwok returned to The University of Sydney as a Lecturer in Pharmaceutical Sciences at the end of July 2017. His research is in pulmonary drug delivery. In particular, he specialises in the engineering, physicochemical characterisation, and electrostatics of pharmaceutical aerosol formulations. He has collaborated with academic and industrial researchers, both locally and internationally, on formulation-focused as well as interdisciplinary projects. Dr Kwok is the theme leader of Therapeutics and Global Health Systems in FungiSphere, a multidisciplinary research node within the Sydney Institute for Infectious Diseases. He is a member of the New South Wales Ministry of Health Poisons Advisory Committee, advising the State Health Secretary on the scheduling of drugs/chemicals and regulatory legislation matters. He is also the student advisor of The University of Sydney AAPS Student Chapter.

Research interests

Dr Kwok's research focuses on drug delivery to the lungs as aerosols to treat local or systemic diseases. This route of administration is challenging because the aerodynamic size and dispersibility of the particles need to be optimal. These goals can be achieved through the use of various particle production techniques (e.g. spray drying, spray freeze drying, nanoparticle formation etc) and the incorporation of excipients, if required, to obtain formulations with desirable aerosolisation, stability, and drug release qualities. The physicochemical properties are evaluated by a range of characterisation methods to obtain optimised formulations, which can be tested on cellular/animal models or potentially in clinical trials.

Teaching and supervision

PHAR2922: Respiratory (Coordinator)

Associations

Honorary assistant professor: Department of Pharmacology and Pharmacy, The University of Hong Kong

Registered pharmacist: Pharmacy Board of Australia

Member: American Association of Pharmaceutical Scientists (AAPS), Asian Federation for Pharmaceutical Sciences (AFPS), American Institute of Chemical Engineers (AIChE), Golden Key International Honour Society

Editorial board member: Journal of Aerosol Medicine and Pulmonary Drug Delivery, Open Pharmaceutical Sciences Journal, Austin Journal of Pharmacology and Therapeutics, Journal of Pharmaceutics and Pharmacology

Journal manuscript reviewer: Journal of Aerosol Medicine and Pulmonary Drug Delivery, International Journal of Pharmaceutics, Pharmaceutical Research, Aerosol Science and Technology, Drug Discovery Today, Journal of Drug Targeting, Nano Letters, Expert Opinion on Drug Delivery, Drug Development and Industrial Pharmacy, Asian Journal of Pharmaceutical Sciences, Multidisciplinary Respiratory Medicine, Crystal Growth & Design, Journal of Colloid and Interface Science, Colloids and Surfaces B: Biointerfaces; Journal of Peptide Science

Grant proposal reviewer: National Health and Medical Research Council of Australia (May 2018), National Science Centre of Poland (April 2015), Health Research Council of New Zealand (February 2015)

Justice of the Peace: New South Wales Department of Justice

Awards and honours

AbVance Commercialisation Award, NSW Drug Discovery Forum 2024, Sydney, Australia, 29 October 2024.

Faculty of Medicine and Health Makers and Shapers Award for Teach Excellence (Team), The University of Sydney, Australia, 28 April 2022.

Fellow of the Higher Education Academy, Advance HE, United Kingdom (Fellowship reference PR238573), 21 March 2022.

Asian Federation for Pharmaceutical Sciences (AFPS) Nagai-Shukri Best Paper Award and AFPS Nagai-Shukri Oral Presentation Award, AFPS Conference 2009, Fukuoka, Japan.

New Investigator Best Oral Presentation, Australasian Pharmaceutical Science Association Conference 2007, Sydney, Australia.

Australian Postgraduate Award (APA), 2003–2006.

Themes

Respiratory Disease

Keywords

Asthma, Lung diseases, Pharmacy, Pharmaceutics, Pharmaceutical

Approaches

Animal Models, Chemistry

Current research students

Project title	Research student
Targeting pulmonary bacterial and fungal infections with inhalable repurposed drugs	Pancy KWONG
Pulmonary delivery of probiotic formulations in respiratory infections	Grace YAU

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Book Chapters

Kwok, P., Chan, H. (2019). Solid State Testing of Inhaled Formulations. In Anthony J. Hickey, Sandro R.P. da Rocha (Eds.), Pharmaceutical Inhalation Aerosol Technology, (pp. 523-540). Boca Raton: CRC Press. [More Information]
Buttini, F., Colombo, G., Kwok, P., Wui, W. (2013). Aerodynamic Assessment for Inhalation Products: Fundamentals and Current Pharmacopoeial Methods. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 91-119). Chichester, UK: John Wiley & Sons. [More Information]
Kwok, P., Chan, H. (2011). Pulmonary Delivery of Peptides and Proteins. In Chris Van der Walle (Eds.), Peptide and Protein Delivery, (pp. 23-46). London, UK: Academic Press. [More Information]
Kwok, P., Chan, H. (2007). Electrostatic Charge in Pharmaceutical Systems. In James Swarbrick and James C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, (pp. 1535-1547). New York, USA: Marcel Dekker.

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Journals

Tai, W., Yau, G., Arnold, J., Chan, H., Kwok, P. (2024). High-loading cannabidiol powders for inhalation. International Journal of Pharmaceutics, 660, 124370. [More Information]
Fen Neoh, C., Jeong, W., Kong, D., Beardsley, J., Kwok, P., Slavin, M., Chen, S. (2024). New and emerging roles for inhalational and direct antifungal drug delivery approaches for treatment of invasive fungal infections. Expert Review of Anti-Infective Therapy. [More Information]
Byun, A., Vitetta, L., Chan, H., Kwok, P. (2024). Respiratory Delivery of Lacticaseibacillus rhamnosus GG by Vibrating-Mesh and Jet Nebulisation. Pharmaceutics, 16(10), 1326. [More Information]
Tai, W., Arnold, J., Chan, H., Kwok, P. (2024). Spray freeze dried cannabidiol with dipalmitoylphosphatidylcholine (DPPC) for inhalation and solubility enhancement. International Journal of Pharmaceutics, 659, 124235. [More Information]
Yau, G., Tai, W., Arnold, J., Chan, H., Kwok, P. (2023). Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration. Pharmaceutical Research. [More Information]
Chan, H., Chow, S., Zhang, X., Kwok, P., Chow, S. (2023). Role of Particle Size in Translational Research of Nanomedicines for Successful Drug Delivery: Discrepancies and Inadequacies. Journal of Pharmaceutical Sciences, 112(9), 2371-2384. [More Information]
Mohammed, Y., Holmes, A., Kwok, P., Kumeria, T., Namjoshi, S., Imran, M., Matteucci, L., Ali, M., Tai, W., Benson, H., et al (2022). Advances and future perspectives in epithelial drug delivery. Advanced Drug Delivery Reviews, 186. [More Information]
Liu, C., Hong, Q., Chang, R., Kwok, P., Chan, H. (2022). Phage-Antibiotic Therapy as a Promising Strategy to Combat Multidrug-Resistant Infections and to Enhance Antimicrobial Efficiency. Antibiotics, 11(5), 570. [More Information]
Tai, W., Kwok, P. (2022). Recent advances in drug delivery to the central nervous system by inhalation. Expert Opinion on Drug Delivery, 19(5), 539-558. [More Information]
Lim, S., Park, S., Lee, C., Ho, P., Kwok, P., Kang, L. (2021). A 3D printed human upper respiratory tract model for particulate deposition profiling. International Journal of Pharmaceutics, 597, 120307. [More Information]
Ke, W., Chang, R., Kwok, P., Tang, P., Chen, L., Chen, D., Chan, H. (2021). Administration of dry powders during respiratory supports. Annals of Translational Medicine, 9(7), 596. [More Information]
Kwok, P. (2021). Advances in inhalation drug delivery. Current Pharmaceutical Design, 27(12), 1435. [More Information]
Ke, W., Kwok, P., Khanal, D., Chang, R., Chan, H. (2021). Co-spray dried hydrophobic drug formulations with crystalline lactose for inhalation aerosol delivery. International Journal of Pharmaceutics, 602, 120608-1-120608-10. [More Information]
Kwok, P., Li, D., Tang, P., Fincher, L., Browne, E., Finlay, W., Chan, H. (2021). Generation and characterization of electrostatically charged radiolabelled aerosols for lung scintigraphy. Aerosol Science and Technology, 55(6), 640-652. [More Information]
Chow, M., Tai, W., Chang, R., Chan, H., Kwok, P. (2021). In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols. Advanced Drug Delivery Reviews, 177, 113952-1-113952-10. [More Information]
Hickey, A., Kwok, P. (2021). In vitro-in vivo correlation of pharmaceutical aerosols. Advanced Drug Delivery Reviews, 179, 114025. [More Information]
Albariqi, A., Chang, R., Tai, W., Ke, W., Chow, M., Tang, P., Kwok, P., Chan, H. (2021). Inhalable Hydroxychloroquine Powders for Potential Treatment of COVID-19. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 34(1), 20-31. [More Information]
Tai, W., Chow, M., Chang, R., Tang, P., Chan, H., Kwok, P. (2021). Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19. Pharmaceutics, 13(8), 1260. [More Information]
Shao, Z., Tai, W., Qiu, Y., Man, R., Liao, Q., Chow, M., Kwok, P., Lam, J. (2021). Spray-dried powder formulation of capreomycin designed for inhaled tuberculosis therapy. Pharmaceutics, 13(12), 2044. [More Information]
Komalla, V., Allam, V., Kwok, P., Sheikholeslami, B., Owen, L., Jaffe, A., Al Nadaf, S., Mohammad, S., Oliver, B., Chen, H., et al (2020). A phospholipid-based formulation for the treatment of airway inflammation in chronic respiratory diseases. European Journal of Pharmaceutics and Biopharmaceutics, 157, 47-58. [More Information]
Wan, K., Weng, J., Wong, S., Kwok, P., Chow, S., Chow, A. (2020). Converting nanosuspension into inhalable and redispersible nanoparticles by combined in-situ thermal gelation and spray drying. European Journal of Pharmaceutics and Biopharmaceutics, 149, 238-247. [More Information]
Chang, R., Kwok, P., Ghassabian, S., Brannan, J., Koskela, H., Chan, H. (2020). Cough as an adverse effect on inhalation pharmaceutical products. British Journal of Pharmacology, 177(18), 4096-4112. [More Information]
Liao, Q., Lam, I., Lin, H., Wan, L., Lo, J., Tai, W., Kwok, P., Lam, J. (2020). Effect of formulation and inhaler parameters on the dispersion of spray freeze dried voriconazole particles. International Journal of Pharmaceutics, 584, 1-11. [More Information]
Kwok, P., McDonnell, A., Tang, P., Knight, C., McKay, E., Butler, S., Sivarajah, A., Quinn, R., Fincher, L., Browne, E., Chan, H., et al (2020). In vivo deposition study of a new generation nebuliser utilising hybrid resonant acoustic (HYDRA) technology. International Journal of Pharmaceutics, 580, 119196. [More Information]
Chang, R., Kwok, P., Khanal, D., Morales, S., Kutter, E., Li, J., Chan, H. (2020). Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization. Bioengineering & Translational Medicine, 5(2), 1-10. [More Information]
Chen, G., Xu, Y., Kwok, P., Kang, L. (2020). Pharmaceutical Applications of 3D Printing. Additive Manufacturing, 34, 101209. [More Information]
Chow, M., Kwok, P., Yang, R., Chan, H. (2020). Predicting the composition and size distribution of dry particles for aerosols and sprays of suspension: A Monte Carlo approach. International Journal of Pharmaceutics, 582, 119311. [More Information]
Ke, W., Chang, R., Kwok, P., Chen, D., Chan, H. (2020). Spray drying lactose from organic solvent suspensions for aerosol delivery to the lungs. International Journal of Pharmaceutics, 591, 119984. [More Information]
Weng, J., Wong, S., Xu, X., Xuan, B., Wang, C., Chen, R., Sun, C., Lakerveld, R., Kwok, P., Chow, S. (2019). Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying. Crystal Growth and Design, 19(5), 2736-2745. [More Information]
Chow, M., Qiu, Y., Liao, Q., Kwok, P., Chow, S., Chan, H., Lam, J. (2019). High siRNA loading powder for inhalation prepared by co-spray drying with human serum albumin. International Journal of Pharmaceutics, 572, 1-11. [More Information]
Hadiwinoto, G., Kwok, P., Tong, H., Wong, S., Chow, S., Lakerveld, R. (2019). Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation. Industrial and Engineering Chemistry Research, 58(36), 16843-16857. [More Information]
Liao, Q., Yip, L., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2019). Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition. International Journal of Pharmaceutics, 560, 144-154. [More Information]
Ashish Kumar, T., Choong, H., Kwang, Y., Chan, H., Manos, J., Kwok, P., Duong, H. (2019). Spray-Dried Particles of Nitric Oxide-Modified Glutathione for the Treatment of Chronic Lung Infection. Molecular Pharmaceutics, 16(4), 1723-1731. [More Information]
Kwok, P., Chan, H., Wallin, M., Dolovich, M. (2019). Studies of Radioaerosol Deposition in the Respiratory Tract. Seminars in Nuclear Medicine, 49(1), 62-70. [More Information]
Hadiwinoto, G., Kwok, P., Lakerveld, R. (2018). A review on recent technologies for the manufacture of pulmonary drugs. Therapeutic Delivery, 9(1), 47-70. [More Information]
Li, A., Yuen, V., Goulay-Dufay, S., Sheng, Y., Standing, J., Kwok, P., Leung, M., Leung, A., Wong, I., Irwin, M. (2018). Corrigendum to Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine" (Br J Anaesth 2018; 120: 960-968)". British Journal of Anaesthesia, 121(3), 687-687. [More Information]
Li, A., Yuen, V., Goulay-Dufay, S., Sheng, Y., Standing, J., Kwok, P., Leung, M., Leung, A., Wong, I., Irwin, M. (2018). Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine. British Journal of Anaesthesia, 120(5), 960-968. [More Information]
Liang, W., Chan, A., Chow, M., Lo, F., Qiu, Y., Kwok, P., Lam, J. (2018). Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery. Asian Journal of Pharmaceutical Sciences, 13(2), 163-172. [More Information]
Liang, W., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2018). Using Two-Fluid Nozzle for Spray Freeze Drying to Produce Porous Powder Formulation of Naked siRNA for Inhalation. International Journal of Pharmaceutics, 552(1-2), 67-75. [More Information]
Leung, S., Chiow, A., Kwok, P., Ukkonen, A., Chan, H. (2017). Effect of Spacers on the Bipolar Electrostatic Charge Properties of Metered Dose Inhaler Aerosols—A Case Study With Tilade. Journal of Pharmaceutical Sciences, 106(6), 1553-1559. [More Information]
Chow, M., Qiu, Y., Lo, F., Lin, H., Chan, H., Kwok, P., Lam, J. (2017). Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer. International Journal of Pharmaceutics, 530(1-2), 40-52. [More Information]
Wong, J., Kwok, P., Niemela, V., Heng, D., Crapper, J., Chan, H. (2016). Bipolar electrostatic charge and mass distributions of powder aerosols - Effects of inhaler design and inhaler material. Journal of Aerosol Science, 95, 104-117. [More Information]
Li, A., Yeun, M., Goulay-Dufay, S., Kwok, P. (2016). Pharmacokinetics and pharmacodynamics of dexmedetomidine. Drug Development and Industrial Pharmacy, 42(12), 1917-1927. [More Information]
Wong, J., Kwok, P., Chan, H. (2015). Electrostatics in pharmaceutical solids. Chemical Engineering Science, 125, 225-237. [More Information]
Kwok, P. (2015). Electrostatics of pharmaceutical aerosols for pulmonary delivery. Current Pharmaceutical Design, 21(27), 3945-3954.
Kwok, P., Grabarek, A., Chow, M., Lan, Y., Li, J., Casettari, L., Mason, A., Lam, J. (2015). Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis. International Journal of Pharmaceutics, 491(1-2), 367-374. [More Information]
Man, D., Casettari, L., Cespi, M., Bonacucina, G., Palmieri, G., Sze, S., Leung, G., Lam, J., Kwok, P. (2015). Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells. Molecular Pharmaceutics, 12(6), 2112-2125. [More Information]
Wong, K., Wong, R., Zhang, L., Liu, W., NG, T., Shaw, P., Kwok, P., Lai, Y., Zhang, Z., et al (2014). Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. Chinese Medicine, 9(1), 19. [More Information]
Kwok, P., Chan, H. (2014). Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced Drug Delivery Reviews, 73, 83-88. [More Information]
Liang, W., Kwok, P., Chow, M., Tang, P., Mason, A., Chan, H., Lam, J. (2014). Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 64-73. [More Information]
Kwok, P., Chan, H. (2014). Nanotechnology Versus other Techniques in Improving Drug Dissolution. Current Pharmaceutical Design, 20(3), 474-482. [More Information]
D'Addio, S., Chan, J., Kwok, P., Benson, B., Prud'homme, R., Chan, H. (2013). Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying. Pharmaceutical Research, 30(11), 2891-2901. [More Information]
D'Addio, S., Chan, J., Kwok, P., Prud'homme, R., Chan, H. (2012). Constant size, variable density aerosol particles by ultrasonic spray freeze drying. International Journal of Pharmaceutics, 427(2), 185-191. [More Information]
Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807. [More Information]
Ay, C., Yeh, C., Hsu, M., Hurng, H., Kwok, P., Chang, H. (2012). Evaluation of the correlation between focal adhesion kinase phosphorylation and cell adhesion force using "DEP" technology. Sensors, 12(5), 5951-5965. [More Information]
Yamasaki, K., Kwok, P., Fukushige, K., Prud'homme, R., Chan, H. (2011). Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former. International Journal of Pharmaceutics, 420(1), 34-42. [More Information]
Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
Lu, Z., Roohaniesfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering - Part A, 17(11/12), 1651-1661. [More Information]
Chan, H., Kwok, P. (2011). Production methods for nanodrug particles using the bottom-up approach. Advanced Drug Delivery Reviews, 63(6), 406-416. [More Information]
Kumon, M., Kwok, P., Adi, H., Heng, D., Chan, H. (2010). Can low-dose combination products for inhalation be formulated in single crystalline particles? European Journal of Pharmaceutical Sciences, 40(1), 16-24. [More Information]
Kwok, P., Trietsch, S., Kumon, M., Chan, H. (2010). Electrostatic Charge Characteristics of Jet Nebulized Aerosols. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(3), 149-159. [More Information]
Kwok, P., Tunsirikongkon, A., Glover, W., Chan, H. (2010). Formation of Protein Nano-Matrix Particles with Controlled Surface Architecture for Respiratory Drug Delivery. Pharmaceutical Research, 28(4), 788-796. [More Information]
Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
Kwok, P., Chan, H. (2009). Electrostatics of pharmaceutical inhalation aerosols. Journal of Pharmacy and Pharmacology, 61(12), 1587-1599. [More Information]
Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
Kwok, P., Noakes, T., Chan, H. (2008). Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 39(3), 211-226. [More Information]
Kwok, P., Chan, H. (2008). Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols. Pharmaceutical Research, 25(2), 277-288. [More Information]
Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
Kwok, P., Collins, R., Chan, H. (2006). Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 37(12), 1671-1682. [More Information]
Chan, H., Chiou, H., Kwok, P. (2006). The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005. Expert Opinion on Drug Delivery, 3(1), 163-167. [More Information]
Kwok, P., Glover, W., Chan, H. (2005). Electrostatic charge characteristics of aerosols produced from metered dose inhalers. Journal of Pharmaceutical Sciences, 94(12), 2789-2799. [More Information]

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Conferences

Kwok, P., Seungyeon, B., Ong, Y., Bhome, A., Tang, P., Chan, H. (2020). In vitro aerosol performance of originator and generic fixed dose combination metered dose inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Tai, W., Bhome, A., Tang, P., Chan, H., Kwok, P. (2020). In Vitro Aerosol Performance Of Originator And Indian Generic Fixed-dose Combination Dry Powder Inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
Kwok, P., Glover, W., Chan, H. (2009). Aerosol Performance of Bovine Serum Albumin Nano-matrices for Inhalation. Asian Federation for Pharmaceutical Sciences (AFPS) 2009 Conference, Japan: Kumamoto University.
Kwok, P., Adi, H., Chan, H. (2009). Protein Nano-Matrices with Controlled Surface Roughness for Inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Kwok, P., Chan, H. (2008). Solid Forms and Electrostatic Properties of Salbutamol Sulfate. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Kwok, P., Chan, H. (2006). Electrostatic charges of metered dose inhaler aerosols sampled from plastic spacers. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.

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2024

Tai, W., Yau, G., Arnold, J., Chan, H., Kwok, P. (2024). High-loading cannabidiol powders for inhalation. International Journal of Pharmaceutics, 660, 124370. [More Information]
Fen Neoh, C., Jeong, W., Kong, D., Beardsley, J., Kwok, P., Slavin, M., Chen, S. (2024). New and emerging roles for inhalational and direct antifungal drug delivery approaches for treatment of invasive fungal infections. Expert Review of Anti-Infective Therapy. [More Information]
Byun, A., Vitetta, L., Chan, H., Kwok, P. (2024). Respiratory Delivery of Lacticaseibacillus rhamnosus GG by Vibrating-Mesh and Jet Nebulisation. Pharmaceutics, 16(10), 1326. [More Information]
Tai, W., Arnold, J., Chan, H., Kwok, P. (2024). Spray freeze dried cannabidiol with dipalmitoylphosphatidylcholine (DPPC) for inhalation and solubility enhancement. International Journal of Pharmaceutics, 659, 124235. [More Information]

show 1 more

2023

Yau, G., Tai, W., Arnold, J., Chan, H., Kwok, P. (2023). Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration. Pharmaceutical Research. [More Information]
Chan, H., Chow, S., Zhang, X., Kwok, P., Chow, S. (2023). Role of Particle Size in Translational Research of Nanomedicines for Successful Drug Delivery: Discrepancies and Inadequacies. Journal of Pharmaceutical Sciences, 112(9), 2371-2384. [More Information]

2022

Mohammed, Y., Holmes, A., Kwok, P., Kumeria, T., Namjoshi, S., Imran, M., Matteucci, L., Ali, M., Tai, W., Benson, H., et al (2022). Advances and future perspectives in epithelial drug delivery. Advanced Drug Delivery Reviews, 186. [More Information]
Liu, C., Hong, Q., Chang, R., Kwok, P., Chan, H. (2022). Phage-Antibiotic Therapy as a Promising Strategy to Combat Multidrug-Resistant Infections and to Enhance Antimicrobial Efficiency. Antibiotics, 11(5), 570. [More Information]
Tai, W., Kwok, P. (2022). Recent advances in drug delivery to the central nervous system by inhalation. Expert Opinion on Drug Delivery, 19(5), 539-558. [More Information]

2021

Lim, S., Park, S., Lee, C., Ho, P., Kwok, P., Kang, L. (2021). A 3D printed human upper respiratory tract model for particulate deposition profiling. International Journal of Pharmaceutics, 597, 120307. [More Information]
Ke, W., Chang, R., Kwok, P., Tang, P., Chen, L., Chen, D., Chan, H. (2021). Administration of dry powders during respiratory supports. Annals of Translational Medicine, 9(7), 596. [More Information]
Kwok, P. (2021). Advances in inhalation drug delivery. Current Pharmaceutical Design, 27(12), 1435. [More Information]
Ke, W., Kwok, P., Khanal, D., Chang, R., Chan, H. (2021). Co-spray dried hydrophobic drug formulations with crystalline lactose for inhalation aerosol delivery. International Journal of Pharmaceutics, 602, 120608-1-120608-10. [More Information]
Kwok, P., Li, D., Tang, P., Fincher, L., Browne, E., Finlay, W., Chan, H. (2021). Generation and characterization of electrostatically charged radiolabelled aerosols for lung scintigraphy. Aerosol Science and Technology, 55(6), 640-652. [More Information]
Chow, M., Tai, W., Chang, R., Chan, H., Kwok, P. (2021). In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols. Advanced Drug Delivery Reviews, 177, 113952-1-113952-10. [More Information]
Hickey, A., Kwok, P. (2021). In vitro-in vivo correlation of pharmaceutical aerosols. Advanced Drug Delivery Reviews, 179, 114025. [More Information]
Albariqi, A., Chang, R., Tai, W., Ke, W., Chow, M., Tang, P., Kwok, P., Chan, H. (2021). Inhalable Hydroxychloroquine Powders for Potential Treatment of COVID-19. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 34(1), 20-31. [More Information]
Tai, W., Chow, M., Chang, R., Tang, P., Chan, H., Kwok, P. (2021). Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19. Pharmaceutics, 13(8), 1260. [More Information]
Shao, Z., Tai, W., Qiu, Y., Man, R., Liao, Q., Chow, M., Kwok, P., Lam, J. (2021). Spray-dried powder formulation of capreomycin designed for inhaled tuberculosis therapy. Pharmaceutics, 13(12), 2044. [More Information]

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2020

Komalla, V., Allam, V., Kwok, P., Sheikholeslami, B., Owen, L., Jaffe, A., Al Nadaf, S., Mohammad, S., Oliver, B., Chen, H., et al (2020). A phospholipid-based formulation for the treatment of airway inflammation in chronic respiratory diseases. European Journal of Pharmaceutics and Biopharmaceutics, 157, 47-58. [More Information]
Wan, K., Weng, J., Wong, S., Kwok, P., Chow, S., Chow, A. (2020). Converting nanosuspension into inhalable and redispersible nanoparticles by combined in-situ thermal gelation and spray drying. European Journal of Pharmaceutics and Biopharmaceutics, 149, 238-247. [More Information]
Chang, R., Kwok, P., Ghassabian, S., Brannan, J., Koskela, H., Chan, H. (2020). Cough as an adverse effect on inhalation pharmaceutical products. British Journal of Pharmacology, 177(18), 4096-4112. [More Information]
Liao, Q., Lam, I., Lin, H., Wan, L., Lo, J., Tai, W., Kwok, P., Lam, J. (2020). Effect of formulation and inhaler parameters on the dispersion of spray freeze dried voriconazole particles. International Journal of Pharmaceutics, 584, 1-11. [More Information]
Kwok, P., Seungyeon, B., Ong, Y., Bhome, A., Tang, P., Chan, H. (2020). In vitro aerosol performance of originator and generic fixed dose combination metered dose inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Tai, W., Bhome, A., Tang, P., Chan, H., Kwok, P. (2020). In Vitro Aerosol Performance Of Originator And Indian Generic Fixed-dose Combination Dry Powder Inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Kwok, P., McDonnell, A., Tang, P., Knight, C., McKay, E., Butler, S., Sivarajah, A., Quinn, R., Fincher, L., Browne, E., Chan, H., et al (2020). In vivo deposition study of a new generation nebuliser utilising hybrid resonant acoustic (HYDRA) technology. International Journal of Pharmaceutics, 580, 119196. [More Information]
Chang, R., Kwok, P., Khanal, D., Morales, S., Kutter, E., Li, J., Chan, H. (2020). Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization. Bioengineering & Translational Medicine, 5(2), 1-10. [More Information]
Chen, G., Xu, Y., Kwok, P., Kang, L. (2020). Pharmaceutical Applications of 3D Printing. Additive Manufacturing, 34, 101209. [More Information]
Chow, M., Kwok, P., Yang, R., Chan, H. (2020). Predicting the composition and size distribution of dry particles for aerosols and sprays of suspension: A Monte Carlo approach. International Journal of Pharmaceutics, 582, 119311. [More Information]
Ke, W., Chang, R., Kwok, P., Chen, D., Chan, H. (2020). Spray drying lactose from organic solvent suspensions for aerosol delivery to the lungs. International Journal of Pharmaceutics, 591, 119984. [More Information]

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2019

Weng, J., Wong, S., Xu, X., Xuan, B., Wang, C., Chen, R., Sun, C., Lakerveld, R., Kwok, P., Chow, S. (2019). Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying. Crystal Growth and Design, 19(5), 2736-2745. [More Information]
Chow, M., Qiu, Y., Liao, Q., Kwok, P., Chow, S., Chan, H., Lam, J. (2019). High siRNA loading powder for inhalation prepared by co-spray drying with human serum albumin. International Journal of Pharmaceutics, 572, 1-11. [More Information]
Hadiwinoto, G., Kwok, P., Tong, H., Wong, S., Chow, S., Lakerveld, R. (2019). Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation. Industrial and Engineering Chemistry Research, 58(36), 16843-16857. [More Information]
Liao, Q., Yip, L., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2019). Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition. International Journal of Pharmaceutics, 560, 144-154. [More Information]
Kwok, P., Chan, H. (2019). Solid State Testing of Inhaled Formulations. In Anthony J. Hickey, Sandro R.P. da Rocha (Eds.), Pharmaceutical Inhalation Aerosol Technology, (pp. 523-540). Boca Raton: CRC Press. [More Information]
Ashish Kumar, T., Choong, H., Kwang, Y., Chan, H., Manos, J., Kwok, P., Duong, H. (2019). Spray-Dried Particles of Nitric Oxide-Modified Glutathione for the Treatment of Chronic Lung Infection. Molecular Pharmaceutics, 16(4), 1723-1731. [More Information]
Kwok, P., Chan, H., Wallin, M., Dolovich, M. (2019). Studies of Radioaerosol Deposition in the Respiratory Tract. Seminars in Nuclear Medicine, 49(1), 62-70. [More Information]

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2018

Hadiwinoto, G., Kwok, P., Lakerveld, R. (2018). A review on recent technologies for the manufacture of pulmonary drugs. Therapeutic Delivery, 9(1), 47-70. [More Information]
Li, A., Yuen, V., Goulay-Dufay, S., Sheng, Y., Standing, J., Kwok, P., Leung, M., Leung, A., Wong, I., Irwin, M. (2018). Corrigendum to Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine" (Br J Anaesth 2018; 120: 960-968)". British Journal of Anaesthesia, 121(3), 687-687. [More Information]
Li, A., Yuen, V., Goulay-Dufay, S., Sheng, Y., Standing, J., Kwok, P., Leung, M., Leung, A., Wong, I., Irwin, M. (2018). Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine. British Journal of Anaesthesia, 120(5), 960-968. [More Information]
Liang, W., Chan, A., Chow, M., Lo, F., Qiu, Y., Kwok, P., Lam, J. (2018). Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery. Asian Journal of Pharmaceutical Sciences, 13(2), 163-172. [More Information]
Liang, W., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2018). Using Two-Fluid Nozzle for Spray Freeze Drying to Produce Porous Powder Formulation of Naked siRNA for Inhalation. International Journal of Pharmaceutics, 552(1-2), 67-75. [More Information]

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2017

Leung, S., Chiow, A., Kwok, P., Ukkonen, A., Chan, H. (2017). Effect of Spacers on the Bipolar Electrostatic Charge Properties of Metered Dose Inhaler Aerosols—A Case Study With Tilade. Journal of Pharmaceutical Sciences, 106(6), 1553-1559. [More Information]
Chow, M., Qiu, Y., Lo, F., Lin, H., Chan, H., Kwok, P., Lam, J. (2017). Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer. International Journal of Pharmaceutics, 530(1-2), 40-52. [More Information]

2016

Wong, J., Kwok, P., Niemela, V., Heng, D., Crapper, J., Chan, H. (2016). Bipolar electrostatic charge and mass distributions of powder aerosols - Effects of inhaler design and inhaler material. Journal of Aerosol Science, 95, 104-117. [More Information]
Li, A., Yeun, M., Goulay-Dufay, S., Kwok, P. (2016). Pharmacokinetics and pharmacodynamics of dexmedetomidine. Drug Development and Industrial Pharmacy, 42(12), 1917-1927. [More Information]

2015

Wong, J., Kwok, P., Chan, H. (2015). Electrostatics in pharmaceutical solids. Chemical Engineering Science, 125, 225-237. [More Information]
Kwok, P. (2015). Electrostatics of pharmaceutical aerosols for pulmonary delivery. Current Pharmaceutical Design, 21(27), 3945-3954.
Kwok, P., Grabarek, A., Chow, M., Lan, Y., Li, J., Casettari, L., Mason, A., Lam, J. (2015). Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis. International Journal of Pharmaceutics, 491(1-2), 367-374. [More Information]
Man, D., Casettari, L., Cespi, M., Bonacucina, G., Palmieri, G., Sze, S., Leung, G., Lam, J., Kwok, P. (2015). Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells. Molecular Pharmaceutics, 12(6), 2112-2125. [More Information]

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2014

Wong, K., Wong, R., Zhang, L., Liu, W., NG, T., Shaw, P., Kwok, P., Lai, Y., Zhang, Z., et al (2014). Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. Chinese Medicine, 9(1), 19. [More Information]
Kwok, P., Chan, H. (2014). Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced Drug Delivery Reviews, 73, 83-88. [More Information]
Liang, W., Kwok, P., Chow, M., Tang, P., Mason, A., Chan, H., Lam, J. (2014). Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 64-73. [More Information]
Kwok, P., Chan, H. (2014). Nanotechnology Versus other Techniques in Improving Drug Dissolution. Current Pharmaceutical Design, 20(3), 474-482. [More Information]

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2013

Buttini, F., Colombo, G., Kwok, P., Wui, W. (2013). Aerodynamic Assessment for Inhalation Products: Fundamentals and Current Pharmacopoeial Methods. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 91-119). Chichester, UK: John Wiley & Sons. [More Information]
D'Addio, S., Chan, J., Kwok, P., Benson, B., Prud'homme, R., Chan, H. (2013). Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying. Pharmaceutical Research, 30(11), 2891-2901. [More Information]

2012

D'Addio, S., Chan, J., Kwok, P., Prud'homme, R., Chan, H. (2012). Constant size, variable density aerosol particles by ultrasonic spray freeze drying. International Journal of Pharmaceutics, 427(2), 185-191. [More Information]
Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807. [More Information]
Ay, C., Yeh, C., Hsu, M., Hurng, H., Kwok, P., Chang, H. (2012). Evaluation of the correlation between focal adhesion kinase phosphorylation and cell adhesion force using "DEP" technology. Sensors, 12(5), 5951-5965. [More Information]

2011

Yamasaki, K., Kwok, P., Fukushige, K., Prud'homme, R., Chan, H. (2011). Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former. International Journal of Pharmaceutics, 420(1), 34-42. [More Information]
Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
Lu, Z., Roohaniesfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering - Part A, 17(11/12), 1651-1661. [More Information]
Chan, H., Kwok, P. (2011). Production methods for nanodrug particles using the bottom-up approach. Advanced Drug Delivery Reviews, 63(6), 406-416. [More Information]
Kwok, P., Chan, H. (2011). Pulmonary Delivery of Peptides and Proteins. In Chris Van der Walle (Eds.), Peptide and Protein Delivery, (pp. 23-46). London, UK: Academic Press. [More Information]
Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.

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2010

Kumon, M., Kwok, P., Adi, H., Heng, D., Chan, H. (2010). Can low-dose combination products for inhalation be formulated in single crystalline particles? European Journal of Pharmaceutical Sciences, 40(1), 16-24. [More Information]
Kwok, P., Trietsch, S., Kumon, M., Chan, H. (2010). Electrostatic Charge Characteristics of Jet Nebulized Aerosols. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(3), 149-159. [More Information]
Kwok, P., Tunsirikongkon, A., Glover, W., Chan, H. (2010). Formation of Protein Nano-Matrix Particles with Controlled Surface Architecture for Respiratory Drug Delivery. Pharmaceutical Research, 28(4), 788-796. [More Information]

2009

Kwok, P., Glover, W., Chan, H. (2009). Aerosol Performance of Bovine Serum Albumin Nano-matrices for Inhalation. Asian Federation for Pharmaceutical Sciences (AFPS) 2009 Conference, Japan: Kumamoto University.
Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
Kwok, P., Chan, H. (2009). Electrostatics of pharmaceutical inhalation aerosols. Journal of Pharmacy and Pharmacology, 61(12), 1587-1599. [More Information]
Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
Kwok, P., Adi, H., Chan, H. (2009). Protein Nano-Matrices with Controlled Surface Roughness for Inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.

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2008

Kwok, P., Noakes, T., Chan, H. (2008). Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 39(3), 211-226. [More Information]
Kwok, P., Chan, H. (2008). Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols. Pharmaceutical Research, 25(2), 277-288. [More Information]
Kwok, P., Chan, H. (2008). Solid Forms and Electrostatic Properties of Salbutamol Sulfate. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.

2007

Kwok, P., Chan, H. (2007). Electrostatic Charge in Pharmaceutical Systems. In James Swarbrick and James C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, (pp. 1535-1547). New York, USA: Marcel Dekker.
Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]

2006

Kwok, P., Collins, R., Chan, H. (2006). Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 37(12), 1671-1682. [More Information]
Kwok, P., Chan, H. (2006). Electrostatic charges of metered dose inhaler aerosols sampled from plastic spacers. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
Chan, H., Chiou, H., Kwok, P. (2006). The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005. Expert Opinion on Drug Delivery, 3(1), 163-167. [More Information]

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2005

Kwok, P., Glover, W., Chan, H. (2005). Electrostatic charge characteristics of aerosols produced from metered dose inhalers. Journal of Pharmaceutical Sciences, 94(12), 2789-2799. [More Information]

Selected Grants

2023

Inhalable pentamidine powder for pulmonary fungal infections, Kwok P, Sydney Institute for Infectious Diseases (Sydney ID)/Sydney ID Seed Grants

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Dr Philip Kwok

Publications

Selected Grants

2023